Already, quite soon after he had come to Rothamstead, his presence had transformed one commonplace tea time to an historic event. It happened one afternoon when he drew a cup of tea from the urn and offered it to the lady beside him, Dr. B. Muriel Bristol, an algologist. She declined it, stating that she preferred a cup into which the milk had been poured first. “Nonsense,” returned Fisher, smiling, “Surely it makes no difference.” But she maintained, with emphasis, that of course it did. From just behind, a voice suggested, “Let’s test her.”
Fascinating anecdote from the life of R.A. Fisher. The link has more on Fisher's exact test and on whether the lady was indeed able to tell the difference between cups.