The Last Lecture
Or Really Achieving Your Childhood Dreams, delivered by Randy Pausch at Carnegie Mellon.
Set aside an hour seventeen minutes to watch this; it's entertaining, useful and moving. To give you another reason, I generally can't stand this sort of 'inspirational' talk, and the fact Randy Pausch was looking forward to 3 to 6 months to live at the time would not be anywhere near enough to sway me over.
One of the best lectures ever delivered; ladies and gentlemen, this is Randy Pausch's Last Lecture:
[embedded video]